068 Lupus Ro60 autoantigen cross-reactivity with commensal Ro60 orthologs

Ro60 peptides induce antibodies to similar epitopes shared among lupus-related autoantigens.

The coexistence of autoantibodies to ribonucleoproteins (RNP) in sera of patients with systemic lupus erythematosus has been attributed to intermolecular determinant spreading among physically associated proteins. Recently, we showed that murine Ab responses to rRo60 or Ro60 peptides were diversified unexpectedly to small nuclear RNP. In this investigation, the mechanisms for this autoantibody ...

Ro60 and La ribonucleoproteins become self-aggregated by cell stress.

Ro and La antigens are of clinical interest in subacute cutaneous lupus erythematosus because skin lesions appear after UV irradiation, which induces the translocation of intracellular Ro and La ribonucleoproteins and trigger autoantibody production. Present studies address the question whether cellular stressors modify molecular characteristics and distribution of Ro60 and La proteins. To acco...

Evidence for multiple shared antigenic determinants within Ro60 and other lupus-related ribonucleoprotein autoantigens in human autoimmune responses.

Ab responses directed against several ribonucleoprotein (RNP) Ags are a characteristic feature of systemic lupus erythematosus (SLE). Previous work in our laboratory using mouse model systems had revealed that both epitope spreading and inherent cross-reactivity between ribonucleoproteins contributes to the observed multiple specificities in autoimmune sera. We have now extended these studies t...

Cardiac Manifestations of Neonatal Lupus Exposure and Inflammation Associated with Ro60 Requires Y3 RNA for Cell Surface

Common and Specific Associations of Anti-SSA/Ro60 and Anti-Ro52/TRIM21 Antibodies in Systemic Lupus Erythematosus

Little information exists about the association of anti-SSA/Ro60 and anti-Ro52/TRIM21 with systemic lupus erytematosus (SLE) features. In this work, we analysed the associations of both anti-Ro reactivities with clinical and immunological manifestations in 141 SLE patients. Photosensitivity and xerophtalmia/xerostomia were found to be positively associated with both anti-SSA/Ro60 (P = 0.024 and...